Has network meta-analysis resolved the controversies related to bowel preparation in elective colorectal surgery?

ABSTRACT:

Aim

There are discrepancies in the guidelines on preparation for colorectal surgery. While intravenous antibiotics (IV) are usually administered, the use of mechanical bowel preparation (MBP) and/or oral antibiotics (OA) is controversial. A recent network meta-analysis (NMA) demonstrated that the addition of OA reduced incisional surgical site infections (iSSIs) by more than 50%. We aimed to perform a NMA including only the highest quality randomized clinical trials (RCTs) in order to determine the ranking of different treatment strategies and assess these RCTs for methodological problems that may affect the conclusions of the NMAs.

Method

A NMA was performed according to PRISMA guidelines. RCTs of adult patients undergoing elective colorectal surgery with appropriate antibi

SUBMITTER: Woodfield JC 

PROVIDER: S-EPMC9796252 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature