Motor function and safety after allogeneic cord blood and cord tissue-derived mesenchymal stromal cells in cerebral palsy: An open-label, randomized trial.

ABSTRACT:

Aim

To evaluate safety and motor function after treatment with allogeneic umbilical cord blood (AlloCB) or umbilical cord tissue-derived mesenchymal stromal cells (hCT-MSC) in children with cerebral palsy (CP).

Method

Ninety-one children (52 males, 39 females; median age 3 years 7 months [range 2-5 years]) with CP due to hypoxic-ischemic encephalopathy, stroke, or periventricular leukomalacia were randomized to three arms: (1) the AlloCB group received 10 × 10⁷ AlloCB total nucleated cells (TNC) per kilogram at baseline (n = 31); (2) the hCT-MSC group received 2 × 10⁶ hCT-MSC at baseline, 3 months, and 6 months (n = 28); (3) the natural history control group received 10 × 10⁷ AlloCB TNC per kilogram at 12 months (n = 31). Motor function was a

SUBMITTER: Sun JM 

PROVIDER: S-EPMC9796267 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature