Using the Vitiligo Noticeability Scale in clinical trials: construct validity, interpretability, reliability and acceptability.

ABSTRACT:

Background

Validated outcome measures are needed for vitiligo trials.

Objectives

To assess construct validity, interpretability, reliability and acceptability of the Vitiligo Noticeability Scale (VNS).

Methods

We used images of vitiligo before and after treatment, plus outcome data, from the HI-Light Vitiligo trial. We compared outcome assessments made by trial participants with assessments of images by clinicians and people with vitiligo who were not trial participants [Patient and Public Involvement (PPI) panel]. Hypothesis testing assessed psychometric properties of the VNS, with κ statistics to assess agreement between outcomes. Three focus groups and two online discussion groups provided insight into the use of VNS by people with vitiligo.

Results

Our hypo

SUBMITTER: Batchelor JM 

PROVIDER: S-EPMC9796274 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature