Detection frequencies and viral load distribution of parvovirus B19 DNA in blood and plasma donations in England.

ABSTRACT:

Background and objectives

Infections with human parvovirus B19 (B19V) are transmissible by blood components and plasma-derived medicines. The European Pharmacopoeia regulates maximum levels of virus allowed in manufacturers' plasma pools. To evaluate contamination risk prior to re-introduction of UK-sourced plasma for manufacturing, we investigated viraemia frequencies of B19V in plasma samples collected from blood donors before and during COVID-enforced lockdown.

Materials and methods

Quantitative PCR for B19V DNA was used to screen pools of 96 anonymised plasma samples collected in England from 2017 (n = 29 505), 2020 (n = 3360) and 2021 (n = 43 200). Selected positive pools were resolved into individual samples. Data on donor notifications and related lookback investigati

SUBMITTER: Williams S 

PROVIDER: S-EPMC9796365 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature