Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials.

ABSTRACT:

Background

Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4).

Objective

To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies.

Methods

We pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of

SUBMITTER: Lyko C 

PROVIDER: S-EPMC9796496 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature