Genome-wide decrease in DNA methylation in adults with epilepsy treated with modified ketogenic diet: A prospective study.

ABSTRACT:

Objective

The aim of this study was to investigate the impact of the modified ketogenic diet on DNA methylation in adults with epilepsy.

Methods

In this prospective study, we investigated the genome-wide DNA methylation in whole blood in 58 adults with epilepsy treated with the modified ketogenic for 12 weeks. Patients were recruited from the National Center for Epilepsy, Norway, from March 1, 2011 to February 28, 2017. DNA methylation was analyzed using the Illumina Infinium MethylationEPIC BeadChip array. Analysis of variance and paired t-test were used to identify differentially methylated loci after 4 and 12 weeks of dietary treatment. A false discovery rate approach with a significance threshold of <5% was used to adjust for multiple comparisons.

Results

We obser

SUBMITTER: Pedersen S 

PROVIDER: S-EPMC9796519 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature