Vasorin plays a critical role in vascular smooth muscle cells and arterial functions.

ABSTRACT: Within the cardiovascular system, the protein vasorin (Vasn) is predominantly expressed by vascular smooth muscle cells (VSMCs) in the coronary arteries and the aorta. Vasn knockout (Vasn^-/- ) mice die within 3 weeks of birth. In the present study, we investigated the role of vascular Vasn expression on vascular function. We used inducible Vasn knockout mice (Vasn^{CRE-ERT KO} and Vasn^{SMMHC-CRE-ERT2 KO} , in which respectively all cells or SMCs only are targeted) to analyze the consequences of total or selective Vasn loss on vascular function. Furthermore, in vivo effects were investigated in vitro using human VSMCs. The death of Vasn^{CRE-ERT KO} mice 21 days after tamoxifen injection was concomitant with decreases in blood pressure, angiotensin II lev

SUBMITTER: Louvet L 

PROVIDER: S-EPMC9796581 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature