Improved growth with growth hormone treatment in children after hematopoietic stem cell transplantation.

ABSTRACT:

Objective

Hematopoietic stem cell transplantation (HSCT) can be a curative treatment for malignant and nonmalignant diseases in children but is associated with significant late effects including growth failure. Growth hormone treatment (GHRx) is offered to improve growth, but limited data are available on its effect on adult height (AH). We aim to evaluate the effectiveness of GHRx.

Design

Single-center retrospective study.

Patients

Thirty-four patients who had received GHRx for ≥1 year were matched with two controls each, without GHRx, based on sex, indication for HSCT (malignancy, benign haematological disease or immunodeficiency), age at HSCT and conditioning with/without total body irradiation (TBI). All had reached AH.

Measurements

The primary outcome meas

SUBMITTER: Hoekx CA 

PROVIDER: S-EPMC9796667 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature