Temporal and geographical variations in survival of children born with congenital anomalies in Europe: A multi-registry cohort study.

ABSTRACT:

Background

Congenital anomalies are a major cause of perinatal, neonatal and infant mortality.

Objectives

The aim was to investigate temporal changes and geographical variation in survival of children with major congenital anomalies (CA) in different European areas.

Methods

In this population-based linkage cohort study, 17 CA registries members of EUROCAT, the European network for the surveillance of CAs, successfully linked data on 115,219 live births with CAs to mortality records. Registries estimated Kaplan-Meier survival at 28 days and 5 years of age and fitted Cox's proportional hazards models comparing mortality at 1 year and 1-9 years of age for children born during 2005-2014 with those born during 1995-2004. The hazard ratios (HR) from each registry were combi

SUBMITTER: Santoro M 

PROVIDER: S-EPMC9796712 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature