A split-face, blind, randomized placebo-controlled clinical trial investigating the efficacy and safety of hyaluronic acid filler for the correction of atrophic facial scars.

ABSTRACT:

Background

Hyaluronic acid fillers have been studied extensively for facial wrinkles; however, their efficacy for atrophic facial scars has yet to be analyzed in a prospective placebo-controlled study.

Objective

To analyze the efficacy and safety of a hyaluronic acid filler for atrophic facial scars.

Methods & materials

Fifteen subjects were randomized to receive up to 1 ml of VYC-17.5 L on one cheek and up to 1 ml of saline on the other side, with an optional touch-up treatment. Subjects were graded by a live blind evaluator using the Quantitative Global Scarring Grading System (QGSGS) (J Cosmet Dermatol. 2006;5:48), the Global Aesthetic Improvement Scale (GAIS), and Canfield photo-analysis.

Results

According to the blind evaluator, there was a significant red

SUBMITTER: Siperstein R 

PROVIDER: S-EPMC9796717 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature