Adverse effects of levodopa/carbidopa intrajejunal gel treatment: A single-center long-term follow-up study.

ABSTRACT:

Objectives

Levodopa/carbidopa intrajejunal gel (LCIG) is an effective therapeutic strategy to overcome levodopa-induced motor complications in advanced Parkinson's disease (PD). However, it requires invasive percutaneous endoscopic gastrojejunostomy (PEG-J) and may be associated with serious adverse effects (AE). In this study, we aimed to evaluate long-term AEs related to LCIG treatment in a large homogenous cohort of advanced PD patients.

Methods

One hundred three consecutive PD patients were regularly monitored for LCIG-related, PEG-J-related, and device-related AEs up to 14 years. Incidence of AEs was studied in time applying a time-to-event analysis and Cox proportional hazard model with age, disease duration, gender, and recurrent AE as covariates. Health-related quali

SUBMITTER: Rus T 

PROVIDER: S-EPMC9796727 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature