Espin overexpression causes stereocilia defects and provides an anti-capping effect on actin polymerization.

ABSTRACT: Stereocilia are actin-based projections of hair cells that are arranged in a step like array, in rows of increasing height, and that constitute the mechanosensory organelle used for the senses of hearing and balance. In order to function properly, stereocilia must attain precise sizes in different hair cell types and must coordinately form distinct rows with varying lengths. Espins are actin-bundling proteins that have a well-characterized role in stereocilia formation; loss of function mutations in Espin result in shorter stereocilia and deafness in the jerker mouse. Here we describe the generation of an Espin overexpressing transgenic mouse line that results in longer first row stereocilia and discoordination of second-row stereocilia length. Furthermore, Espin overexpression results in

SUBMITTER: Zheng L 

PROVIDER: S-EPMC9796729 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature