SET domain containing 2 (SETD2) influences metabolism and alternative splicing during myogenesis.

ABSTRACT: Epigenetic regulatory mechanisms are increasingly recognized as crucial determinants of cellular specification and differentiation. During muscle cell differentiation (myogenesis), extensive remodelling of histone acetylation and methylation occurs. Several of these histone modifications aid in the expression of muscle-specific genes and the silencing of genes that block lineage commitment. Therefore, the identification of new epigenetic regulatory mechanisms is of high interest. Still, the functional relevance of numerous histone modifications during myogenesis remain completely uncertain. In this study, we focus on the function of H3K36me3 and its epigenetic writer, SET domain containing 2 (SETD2), in the context of muscle cell differentiation. We first observed that SETD2 expression inc

SUBMITTER: Wiedner HJ 

PROVIDER: S-EPMC9796740 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature