Spouse bereavement and brain pathologies: A propensity score matching study.

ABSTRACT:

Aim

Spouse bereavement is one of life's greatest stresses and has been suggested to trigger or accelerate cognitive decline and dementia. However, little information is available about the potential brain pathologies underlying the association between spouse bereavement and cognitive decline. We aimed to investigate that lifetime spouse bereavement is associated with in vivo human brain pathologies underlying cognitive decline.

Methods

A total of 319 ever-married older adults between the ages of 61 and 90 years underwent comprehensive clinical assessments and multimodal brain imaging including [¹¹ C] Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, [¹⁸ F] fluorodeoxyglucose-PET, and magnetic resonance imaging. Participants were cla

SUBMITTER: Kim JW 

PROVIDER: S-EPMC9796777 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature