Hypothermic oxygenated perfusion in extended criteria donor liver transplantation-A randomized clinical trial.

ABSTRACT: Hypothermic Oxygenated Perfusion (HOPE) of the liver can reduce the incidence of early allograft dysfunction (EAD) and failure in extended criteria donors (ECD) grafts, although data from prospective studies are very limited. In this monocentric, open-label study, from December 2018 to January 2021, 110 patients undergoing transplantation of an ECD liver graft were randomized to receive a liver after HOPE or after static cold storage (SCS) alone. The primary endpoint was the incidence of EAD. The secondary endpoints included graft and patient survival, the EASE risk score, and the rate of graft or other graft-related complications. Patients in the HOPE group had a significantly lower rate of EAD (13% vs. 35%, p = .007) and were more frequently allocated to the intermediate or higher risk g

SUBMITTER: Ravaioli M 

PROVIDER: S-EPMC9796786 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature