CUSUMIN: A cumulative sum interval design for cancer phase I dose finding studies.

ABSTRACT: Recently, model-assisted designs, including the Bayesian optimal interval (BOIN) design with optimal thresholds to determine the dose for the next cohort, have been proposed for cancer phase I studies. Model-assisted designs are useful because of their good performance as model-based designs in addition to their algorithm-based simplicity. In BOIN, escalation and de-escalation based on boundaries can be understood as a type of change point detection based on a sequential test procedure. Notably, the sequential test procedure is used in a wide range of fields and is known for its application to control charts, statistical monitoring methods used for detecting abnormalities in manufacturing processes. In control charts, abnormalities are detected if the control chart statistics are observed

SUBMITTER: Hatayama T 

PROVIDER: S-EPMC9796866 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature