Role of the CrcB transporter of Pseudomonas putida in the multi-level stress response elicited by mineral fluoride.

ABSTRACT: The presence of mineral fluoride (F^- ) in the environment has both a geogenic and anthropogenic origin, and the halide has been described to be toxic in virtually all living organisms. While the evidence gathered in different microbial species supports this notion, a systematic exploration of the effects of F^- salts on the metabolism and physiology of environmental bacteria remained underexplored thus far. In this work, we studied and characterized tolerance mechanisms deployed by the model soil bacterium Pseudomonas putida KT2440 against NaF. By adopting systems-level omic approaches, including functional genomics and metabolomics, we gauged the impact of this anion at different regulatory levels under conditions that impair bacterial growth. Several genes involved i

SUBMITTER: Calero P 

PROVIDER: S-EPMC9796867 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature