The risk of major structural birth defects associated with seasonal influenza vaccination during pregnancy: A population-based cohort study.

ABSTRACT:

Introduction

Seasonal inactivated influenza vaccine (IIV) is routinely recommended during pregnancy to protect both mothers and infants from complications following influenza infection. While previous studies have evaluated the risk of major structural birth defects in infants associated with prenatal administration of monovalent pandemic IIV, fewer studies have evaluated the risk associated with prenatal seasonal IIV.

Methods

We conducted a population-based cohort study of 125,866 singleton births between 2012 and 2016 in Western Australia. Birth registrations were linked to the state's registers for congenital anomalies and a state prenatal vaccination database. We estimated prevalence ratios (PR) of any major structural birth defect and defects by organ system. Vaccinated

SUBMITTER: Sarna M 

PROVIDER: S-EPMC9796878 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature