Factors associated with severity of atopic dermatitis - a Finnish cross-sectional study.

ABSTRACT:

Background

Severity-associated factors in atopic dermatitis (AD) have focussed on early onset, concomitant atopic diseases, markers of Th2-shifted inflammation and filaggrin mutations.

Objectives

To investigate factors associated with severe AD in Finnish patients.

Methods

We conducted a single-centre, cross-sectional observational study with 502 AD patients aged 4.79 to 79.90 years (mean 32.08 years). Disease severity was assessed with the Rajka-Langeland severity score and EASI and associated clinical signs were evaluated. Data regarding onset, relatives, atopic and other comorbidities was gathered retrospectively. We investigated total serum IgE-levels, a panel of filaggrin null mutations and functional variants of genes associated with skin barrier defects.

Res

SUBMITTER: Salava A 

PROVIDER: S-EPMC9796899 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature