Combinations of rapid immunoassays for a speedy diagnosis of heparin-induced thrombocytopenia.

ABSTRACT:

Background

Early recognition and treatment of heparin-induced thrombocytopenia (HIT) are key to prevent severe complications.

Objective

To assess the diagnostic performance of rapid immunoassays (IA) in detecting anti-PF4/heparin-antibodies.

Methods

Diagnostic performances of lateral-flow IA (LFIA; STic Expert HIT) and latex IA (LIA; HemosIL HIT-Ab) were analyzed in pilot (n = 74) and derivation cohorts (n = 267). Two novel algorithms based on the combination of HIT clinical probability with sequentially performed LIA and chemiluminescent IA (CLIA; HemosIL AcuStar-HIT-IgG) were compared with published rapid diagnostic algorithms: the "Lausanne algorithm" sequentially combining CLIA and particle-gel IA (PaGIA) and the "Hamilton algorithm" based on simultaneously perfor

SUBMITTER: Rittener-Ruff L 

PROVIDER: S-EPMC9796930 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature