Construction of an immune-related ceRNA network in cervical cancer based on HPV E6 splicing.

ABSTRACT:

Background

Cervical cancer is one of the leading causes of cancer-related deaths worldwide. The unspliced human papillomavirus (HPV) E6 plays an important role in tumor progression and immune regulation. Improved immunotherapy implementation might benefit from a better knowledge of HPV E6 splicing-related immune gene expressions and immunocyte infiltration in cervical cancer. This study aimed to identify the potential therapeutic and prognostic roles of unspliced/spliced E6 ratio (E6 ratio) in cervical cancer.

Methods

Data from the TCGA were used to analyze the E6 condition and clinical information. Nomogram and K-M analysis were used to analyze assess the prognostic significance, IOBR was used to investigate immunological infiltrates. Functions and pathway enrichment analys

SUBMITTER: Jiang S 

PROVIDER: S-EPMC9796994 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature