Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period.

ABSTRACT: In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether comparable sensitive periods exist for non-sensory cortices, such as the prefrontal cortex, in which alterations in activity determine adult circuit function and behavior is still an active area of research. Here, using mice we demonstrate that inhibition of prefrontal parvalbumin (PV)-expressing interneurons during the juvenile and adolescent period, results in persistent impairments in adult prefrontal circuit connectivity, in vivo network function, and behavioral flexibility that can be reversed by targeted activation of PV interneurons in adul

SUBMITTER: Canetta SE 

PROVIDER: S-EPMC9797185 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature