Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity.

ABSTRACT: Homeostatic synaptic plasticity is a non-Hebbian synaptic mechanism that adjusts synaptic strength to maintain network stability while achieving optimal information processing. Among the molecular mediators shown to regulate this form of plasticity, synaptic signaling through retinoic acid (RA) and its receptor, RARα, has been shown to be critically involved in the homeostatic adjustment of synaptic transmission in both hippocampus and sensory cortices. In this study, we explore the molecular mechanism through which postsynaptic RA and RARα regulates presynaptic neurotransmitter release during prolonged synaptic inactivity at mouse glutamatertic synapses. We show that RARα binds to a subset of dendritically sorted brain-derived neurotrophic factor (Bdnf) mRNA splice isoforms and rep

SUBMITTER: Thapliyal S 

PROVIDER: S-EPMC9797192 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature