Transcriptome analysis of fat accumulation in 3T3-L1 adipocytes induced by chlorantraniliprole.

ABSTRACT:

Introduction

Chlorantraniliprole is a diamide insecticide widely used in agriculture. Chlorantraniliprole has been previously found to increase the accumulation of triglycerides (fats) in adipocytes, however, the underlying molecular mechanism is unknown. The present study aimed to explore the molecular mechanisms of chlorantraniliprole-induced fat accumulation in 3T3-L1 adipocytes.

Methods

We measured the triglyceride content in chlorantraniliprole-treated 3T3-L1 adipocytes, and collected cell samples treated with chlorantraniliprole for 24 h and without any treatment for RNA sequencing.

Results

Compared with the control group, the content of triglyceride in the treatment group of chlorantraniliprole was significantly increased. The results of RNA sequencing (RNA-seq

SUBMITTER: Chen G 

PROVIDER: S-EPMC9797500 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature