Iron status and mental disorders: A Mendelian randomization study.

ABSTRACT:

Background

Mental disorders account for an enormous global burden of disease, and has been associated with disturbed iron metabolism in observational studies. However, such associations are inconsistent and may be attributable to confounding from environmental factors. This study uses a two-sample Mendelian randomization (MR) analysis to investigate whether there is any causal effect of systemic iron status on risk of 24 specific mental disorders.

Methods

Genetic variants with concordant relations to 4 biomarkers of iron status (serum iron, ferritin, transferrin saturation, and transferrin) were obtained from a genome-wide association study performed by the Genetics of Iron Status (GIS) consortium. Summary-level data for mental disorders were obtained from the UK Biobank. An

SUBMITTER: Qiu J 

PROVIDER: S-EPMC9797506 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature