Ontology highlight
ABSTRACT:
SUBMITTER: Xie Y
PROVIDER: S-EPMC9797508 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Xie Yunfeng Y Wang Lei L Yang Yang Y Zha Liang L Zhang Jiazhen J Rong Kuanrong K Tang Wenjian W Zhang Jing J
Frontiers in microbiology 20221215
<i>Enterococcus faecium</i> (<i>E. faecium</i>) is a clinical multidrug-resistant pathogen causing life-threatening infection, which makes it important to discover antibacterial agents with novel scaffolds and unique mechanism. In this study, the diarylurea scaffold was found to have potent antibacterial effect on <i>E. faecium</i>. Diarylurea <b>ZJ-2</b> with benign drug-like property exhibited potent antibacterial and anti-biofilm activity through inhibiting the genes expression of NlpC/p60 hy ...[more]