The blood pressure targets in sepsis patients with acute kidney injury: An observational cohort study of multiple ICUs.

ABSTRACT:

Background

The maintenance of blood pressure is pivotal in preventing sepsis with acute kidney injury (AKI). Especially in sepsis patients treated with vasopressors. The optimal the blood pressure has been controversial to maintain renal perfusion. This study aims to explore the blood pressure target in sepsis with AKI.

Methods

We retrieved patient data from the MIMIC IV and eICU databases. The Lasso regression model was used to identify the relationship between blood pressure and sepsis in patients with AKI and remove collinearity among variables. Generalized additive models were used to estimate the blood pressure range in patients with sepsis with AKI. Statistical methods such as multivariable logistic regression, propensity score analysis, inversion probability-weighting

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9797512 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature