Transcriptome profiling of osteoclast subsets associated with arthritis: A pathogenic role of CCR2^hi osteoclast progenitors.

ABSTRACT:

Introduction

The existence of different osteoclast progenitor (OCP) subsets has been confirmed by numerous studies. However, pathological inflammation-induced osteoclastogenesis remains incompletely understood. Detailed characterization of OCP subsets may elucidate the pathophysiology of increased osteoclast activity causing periarticular and systemic bone resorption in arthritis. In our study, we rely on previously defined OCP subsets categorized by the level of CCR2 expression as circulatory-like committed CCR2^hi OCPs, which are substantially expanded in arthritis, and marrow-resident CCR2^lo OCPs of immature phenotype and behavior.

Methods

In order to perform transcriptome characterization of those subsets in the context of collagen-induced arthritis

SUBMITTER: Filipovic M 

PROVIDER: S-EPMC9797520 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature