Survival of Locally Advanced MSI-high Gastric Cancer Patients Treated With Perioperative Chemotherapy: A Retrospective Cohort Study.

ABSTRACT:

Objective

To evaluate the efficacy of chemotherapy in patients with microsatellite instability (MSI)-high gastric cancer.

Background

Although MSI-high gastric cancer is associated with a superior prognosis, recent studies question the benefit of perioperative chemotherapy in this population.

Methods

Locally advanced gastric adenocarcinoma patients who either underwent surgery alone or also received neoadjuvant, perioperative, or adjuvant chemotherapy between 2000 and 2018 were eligible. MSI status, determined by next-generation sequencing or mismatch repair protein immunohistochemistry, was determined in 535 patients. Associations among MSI status, chemotherapy administration, overall survival (OS), disease-specific survival, and disease-free survival were assessed.

SUBMITTER: Vos EL 

PROVIDER: S-EPMC9797619 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature