Molecular mechanism of enhanced ethanol tolerance associated with hfq overexpression in Zymomonas mobilis.

ABSTRACT: Zymomonas mobilis is a promising microorganism for industrial bioethanol production. However, ethanol produced during fermentation is toxic to Z. mobilis and affects its growth and bioethanol production. Although several reports demonstrated that the RNA-binding protein Hfq in Z. mobilis contributes to the tolerance against multiple lignocellulosic hydrolysate inhibitors, the role of Hfq on ethanol tolerance has not been investigated. In this study, hfq in Z. mobilis was either deleted or overexpressed and their effects on cell growth and ethanol tolerance were examined. Our results demonstrated that hfq overexpression improved ethanol tolerance of Z. mobilis, which is probably due to energy saving by downregulating flagellar biosynthesis an

SUBMITTER: Tang Y 

PROVIDER: S-EPMC9797736 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature