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In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey.


ABSTRACT:

Background

People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting.

Methods

We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed.

Results

Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%).

Conclusion

Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization's objective of eliminating viral hepatitis.

SUBMITTER: Sarıgul Yıldırım F 

PROVIDER: S-EPMC9797763 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey.

Sarıgül Yıldırım Figen F   Üser Ülkü Ü   Sarı Nagehan Didem ND   Kurtaran Behice B   Önlen Yusuf Y   Şenateş Ebubekir E   Gündüz Alper A   Zerdali Esra E   Karsen Hasan H   Batırel Ayşe A   Karaali Rıdvan R   Güner Rahmet R   Yamazhan Tansu T   Köse Şükran Ş   Erben Nurettin N   İnce Nevin N   Köksal İftihar İ   Çuvalcı Öztoprak Nefise N   Yörük Gülşen G   Kömür Süheyla S   Bal Tayibe T   Kaya Sibel S   Bozkurt İlkay İ   Günal Özgür Ö   Yıldız İlknur Esen İE   İnan Dilara D   Barut Şener Ş   Namıduru Mustafa M   Tosun Selma S   Türker Kamuran K   Şener Alper A   Hızel Kenan K   Baykam Nurcan N   Duygu Fazilet F   Bodur Hürrem H   Can Güray G   Gül Hanefi Cem HC   Sağmak Tartar Ayşe A   Çelebi Güven G   Sünnetçioğlu Mahmut M   Karabay Oğuz O   Kumbasar Karaosmanoğlu Hayat H   Sırmatel Fatma F   Tabak Fehmi F  

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20221101 11


<h4>Background</h4>People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting.<h4>Methods</h4>We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713  ...[more]

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