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ABSTRACT: Background
People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting.Methods
We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed.Results
Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%).Conclusion
Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization's objective of eliminating viral hepatitis.
SUBMITTER: Sarıgul Yıldırım F
PROVIDER: S-EPMC9797763 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Sarıgül Yıldırım Figen F Üser Ülkü Ü Sarı Nagehan Didem ND Kurtaran Behice B Önlen Yusuf Y Şenateş Ebubekir E Gündüz Alper A Zerdali Esra E Karsen Hasan H Batırel Ayşe A Karaali Rıdvan R Güner Rahmet R Yamazhan Tansu T Köse Şükran Ş Erben Nurettin N İnce Nevin N Köksal İftihar İ Çuvalcı Öztoprak Nefise N Yörük Gülşen G Kömür Süheyla S Bal Tayibe T Kaya Sibel S Bozkurt İlkay İ Günal Özgür Ö Yıldız İlknur Esen İE İnan Dilara D Barut Şener Ş Namıduru Mustafa M Tosun Selma S Türker Kamuran K Şener Alper A Hızel Kenan K Baykam Nurcan N Duygu Fazilet F Bodur Hürrem H Can Güray G Gül Hanefi Cem HC Sağmak Tartar Ayşe A Çelebi Güven G Sünnetçioğlu Mahmut M Karabay Oğuz O Kumbasar Karaosmanoğlu Hayat H Sırmatel Fatma F Tabak Fehmi F
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20221101 11
<h4>Background</h4>People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting.<h4>Methods</h4>We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 ...[more]