Glaesserella parasuis autotransporters EspP1 and EspP2 are novel IgA-specific proteases.

ABSTRACT:

Background

Glaesserella parasuis causes Glässer's disease, which is associated with severe polyarthritis, fibrinous polyserositis and meningitis, and leads to significant economic losses to the swine industry worldwide. IgA is one of the most important humoral immune factors present on mucosal surfaces, and it plays a crucial role in neutralizing and removing pathogens. G. parasuis is able to colonize the mucosal membrane of respiratory tract without being eliminated. Nevertheless, the immune evasion mechanism of G. parasuis in thwarting IgA remains unclear.

Aims

The object of this study is to characterize the IgA degradation activity of Mac-1-containing autotransporter EspP1 and EspP2 from G. parasuis.

Methods

The swine IgA was purified an

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9797811 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature