The prenatal weekly temperature exposure and neonatal congenital heart disease: a large population-based observational study in China.

ABSTRACT: We aim to explore the link between maternal weekly temperature exposure and CHD in offspring and identify the relative contributions from heat and cold and from moderate and extreme atmospheric temperature. From January 2019 to December 2020, newborns who were diagnosed with CHD by echocardiography in the Network Platform for Congenital Heart Disease (NPCHD) from 11 cities in eastern China were enrolled in the present study. We appraised the exposure lag response relationship between temperature and CHDs in the distributed lag nonlinear model and further probed the pooled estimates by multivariate meta-analysis. We further performed the exposure-response curves in extreme temperature (5^th percentile for cold and 95^th for hot events). We also delve into the cumulative

SUBMITTER: Xu W 

PROVIDER: S-EPMC9797890 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature