Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort

ABSTRACT:

Objective

Hyperuricemia and gout have become gradually more common. The effect of serum urate on organism aging and systematic inflammation is not determined. This study aims to evaluate whether serum urate is causally associated with cellular aging markers and serum inflammation markers.

Methods

A Mendelian randomization study was performed on summary-level data from the largest published genome-wide association studies. Single nucleotide polymorphisms with a genome-wide significance level were selected as instrumental variables for leukocyte telomere length (LTL), and serum soluble makers of inflammation (CRP, IL-6, TNF-α, and IGF-1). Standard inverse variance weighted (IVW) method was used as the primary statistical method. The weighted median, MR-Egger regression, and

SUBMITTER: Lv Z 

PROVIDER: S-EPMC9797991 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature