Characteristics of the immunogenicity and tumor immune microenvironment in HER2-amplified lung adenocarcinoma.

ABSTRACT:

Objective

Besides breast and gastric cancer, HER2 amplification/mutation are also found in lung adenocarcinoma (LUAD). However, the correlation between HER2 variations and the phenotype of immunogenicity and tumor immune microenvironment (TIME) in LUAD compared with breast and gastric cancer has yet to be fully elucidated.

Methods

We integrated public databases (discovery set) and internal data (validated set) of 288 patients representing three distinct HER2-altered tumors. Genomic data were used to identify somatic mutations, copy number variations, and calculate tumor mutational burden (TMB) and microsatellite instability score. RNA sequencing was conducted to estimate immune gene signatures and contents of tumor-infiltrating immune cell populations. F

SUBMITTER: Wang Q 

PROVIDER: S-EPMC9797999 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature