Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth.

ABSTRACT: During infection, Salmonella hijacks essential host signaling pathways. These molecular manipulations disrupt cellular integrity and may induce oncogenic transformation. Systemic S. Typhi infections are linked to gallbladder cancer, whereas severe non-typhoidal Salmonella (NTS) infections are associated with colon cancer (CC). These diagnosed infections, however, represent only a small fraction of all NTS infections as many infections are mild and go unnoticed. To assess the overall impact of NTS infections, we performed a retrospective serological study on NTS exposure in patients with CC. The magnitude of exposure to NTS, as measured by serum antibody titer, is significantly positively associated with CC. Repetitively infecting mice with low NTS exposure showed similar accelerated tumor

SUBMITTER: van Elsland DM 

PROVIDER: S-EPMC9798023 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature