Systematic review reveals sexually antagonistic knockouts in model organisms.

ABSTRACT: Sexual antagonism is thought to be an important selective force in multiple evolutionary processes, but very few examples of the genes involved are known. Such a deficit of loci could partially be explained by the lack of overlap in terminology between scientific disciplines. Following a similar review in humans, we searched systematically for studies that described genes with sexually antagonistic or sex-opposite effects in any taxa, using terms designed to capture alternative descriptions of sexual antagonism. Despite drawing on a potentially very large pool of studies we found only eight articles, which between them described seven candidate variants, five of these were gene knockouts. In every case, the variants had net negative effects on the focal trait. One locus was independently v

SUBMITTER: Harper JA 

PROVIDER: S-EPMC9798040 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature