Antipsychotic exposure is an independent risk factor for breast cancer: A systematic review of epidemiological evidence.

ABSTRACT:

Background

The effect of antipsychotics on breast cancer remains controversial.

Materials and methods

Embase, Scopus, PubMed, Web of Science, Cochrane Library, and Hebei Medical University Library were used for the literature search. Observational studies with original data for the effects of antipsychotics on breast cancer were used. Studies of bed quality, those with inadequate sample size, incomplete follow-up works, or studies that did not meet the criteria were excluded. Meta-analysis was performed using R version 4.1.2. The odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the proportion of breast cancer in different groups. To detect possible sources of heterogeneity, subgroup and meta-regression analyses were employed.

Results

Pooled d

SUBMITTER: Gao Z 

PROVIDER: S-EPMC9798228 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature