Novel investigations in retinoic-acid-induced cleft palate about the gut microbiome of pregnant mice.

ABSTRACT:

Introduction

Cleft palate (CP) is one of the most common congenital birth defects in the craniofacial region, retinoic acid (RA) gavage is the most common method for inducing cleft palate model. Although several mechanisms have been proposed to illuminate RA-induced cleft palate during embryonic development, these findings are far from enough. Many efforts remain to be devoted to studying the etiology and pathogenesis of cleft palate. Recent research is gradually shifting the focus to the effect of retinoic acid on gut microbiota. However, few reports focus on the relationship between the occurrence of CP in embryos and gut microbiota.

Methods

In our research, we used RA to induce cleft palate model for E10.5 the feces of 5 RA-treated pregnant mice and 5 control pregnant mic

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9798234 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature