A role for age-associated alterations in esophageal epithelium in eosinophilic esophagitis-associated fibrosis.

ABSTRACT: Subepithelial fibrosis occurs in a subset of eosinophilic esophagitis (EoE) patients and is associated with esophageal stricture. While mechanisms driving EoE fibrosis remain incompletely understood, findings from experimental systems support roles for epithelial-fibroblast crosstalk in this type of tissue remodeling. The current paradigm presents EoE as a progressive fibrostenotic disease in which aged patients develop fibrosis as a function of disease chronicity. In the current study we provide evidence that altered epithelial biology in the aging esophagus may also contribute to EoE-associated fibrosis. We find that induction of EoE inflammation in young and aged mice using the MC903/Ovalbumin protocol for the same time period results in increased lamina propria thickness uniquely in ag

SUBMITTER: Klochkova A 

PROVIDER: S-EPMC9798296 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature