Causal effect of iron status on lung function: A Mendelian randomization study.

ABSTRACT:

Background

The association between systemic iron status and lung function was conflicting in observational studies. We aim to explore the potential causal relationships between iron status and the levels of lung function using the two-sample Mendelian randomization (MR) design.

Methods

Genetic instruments associated with iron status biomarkers were retrieved from the Genetics of Iron Status (GIS) consortium (N = 48,972). Summary statistics of these genetic instruments with lung function were extracted from a meta-analysis of UK Biobank and SpiroMeta consortium (N = 400,102). The main analyses were performed using the inverse-variance weighted method, and complemented by multiple sensitivity analyses.

Results

Based on conservative genetic instruments, MR

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9798299 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature