Changes in both top-down and bottom-up effective connectivity drive visual hallucinations in Parkinson's disease.

ABSTRACT: Visual hallucinations are common in Parkinson's disease and are associated with a poorer quality of life and a higher risk of dementia. An important and influential model that is widely accepted as an explanation for the mechanism of visual hallucinations in Parkinson's disease and other Lewy body diseases is that these arise due to aberrant hierarchical processing, with impaired bottom-up integration of sensory information and overweighting of top-down perceptual priors within the visual system. This hypothesis has been driven by behavioural data and supported indirectly by observations derived from regional activation and correlational measures using neuroimaging. However, until now, there was no evidence from neuroimaging for differences in causal influences between brain regions measur

SUBMITTER: Thomas GEC 

PROVIDER: S-EPMC9798302 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature