Whole exome sequencing in Chinese mucinous pulmonary adenocarcinoma uncovers specific genetic variations different from lung adenocarcinoma.

ABSTRACT:

Background

As a rare subtype of primary lung adenocarcinoma (LUAD), mucinous pulmonary adenocarcinoma (MPA) was considered a distinctive entity with unfavorable outcomes. Therefore, there is a great need for a better understanding of the genomic and immunological landscape of this rare tumor type, which would inform improved therapeutic strategies.

Methods

A total of 96 patients histologically confirmed with MPA were recruited from Shandong Cancer Hospital and Institute (SCH). Single nucleotide variation (SNV), copy number variation (CNV), genomic instability, and immunological landscape insights into 96 MPA patients were identified using WES.

Results

We demonstrated that MPAs had marked different genomic alterations and were more complex in genomic profiles than LUAD

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9798319 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature