A panel of blood-derived miRNAs with a stable expression pattern as a potential pan-cancer detection signature.

ABSTRACT: Introduction: MicroRNAs have a significant role in the regulation of the transcriptome. Several miRNAs have been proposed as potential biomarkers in different malignancies. However, contradictory results have been reported on the capability of miRNA biomarkers in cancer detection. The human biological clock involves molecular mechanisms that regulate several genes over time. Therefore, the sampling time becomes one of the significant factors in gene expression studies. Method: In the present study, we have tried to find miRNAs with minimum fluctuation in expression levels at different time points that could be more accurate candidates as diagnostic biomarkers. The small RNA-seq raw data of ten healthy individuals across nine-time points were analyzed to identify miRNAs with s

SUBMITTER: Sabbaghian A 

PROVIDER: S-EPMC9798419 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature