Mucosa associated invariant T and natural killer cells in active and budesonide treated collagenous colitis patients.

ABSTRACT:

Introduction

Collagenous colitis (CC) is an inflammatory bowel disease, which usually responds to budesonide treatment. Our aim was to study the immunological background of the disease.

Methods

Analyses of peripheral and mucosal MAIT (mucosa associated invariant T cells) and NK (natural killer) cells were performed with flow cytometry. Numbers of mucosal cells were calculated using immunohistochemistry. We studied the same patients with active untreated CC (au-CC) and again while in remission on budesonide treatment. Budesonide refractory patients and healthy controls were also included. The memory marker CD45R0 and activation marker CD154 and CD69 were used to further study the cells. Finally B cells, CD4⁺ and CD8⁺ T cells were also analysed.

Result

SUBMITTER: Daferera N 

PROVIDER: S-EPMC9798420 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature