Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis.

ABSTRACT:

Background

Assessing the correlation between gut microbiota (GM) and bone homeostasis has increasingly attracted research interest. Meanwhile, GM dysbiosis has been found to be associated with abnormal bone metabolism. However, the function of GM in disuse-induced osteoporosis (DIO) remains poorly understood. In our research, we evaluated the characteristics of GM and fecal metabolomics to explore their potential correlations with DIO pathogenesis.

Methods

DIO rat models and controls (CON) underwent micro-CT, histological analyses, and three-point bending tests; subsequently, bone microstructures and strength were observed. ELISAs were applied for the measurement of the biochemical markers of bone turnover while GM abundance was observed using 16S rDNA sequencing. Metabolomi

SUBMITTER: Qiao X 

PROVIDER: S-EPMC9798431 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature