Immunoproteasome inhibition attenuates experimental psoriasis.

ABSTRACT:

Introduction

Psoriasis is an autoimmune skin disease associated with multiple comorbidities. The immunoproteasome is a special form of the proteasome expressed in cells of hematopoietic origin.

Methods

The therapeutic use of ONX 0914, a selective inhibitor of the immunoproteasome, was investigated in Card14ΔE138^+/- mice, which spontaneously develop psoriasis-like symptoms, and in the imiquimod murine model.

Results

In both models, treatment with ONX 0914 significantly reduced skin thickness, inflammation scores, and pathological lesions in the analyzed skin tissue. Furthermore, immunoproteasome inhibition normalized the expression of several pro-inflammatory genes in the ear and significantly reduced the inflammatory infiltrate, accompanied by a sign

SUBMITTER: Del Rio Oliva M 

PROVIDER: S-EPMC9798438 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature