Construction of cell factory through combinatorial metabolic engineering for efficient production of itaconic acid.

ABSTRACT:

Background

Itaconic acid, an unsaturated C5 dicarbonic acid, has significant market demand and prospects. It has numerous biological functions, such as anti-cancer, anti-inflammatory, and anti-oxidative in medicine, and is an essential renewable platform chemical in industry. However, the development of industrial itaconic acid production by Aspergillus terreus, the current standard production strain, is hampered by the unavoidable drawbacks of that species. Developing a highly efficient cell factory is essential for the sustainable and green production of itaconic acid.

Results

This study employed combinatorial engineering strategies to construct Escherichia coli cells to produce itaconic acid efficiently. Two essential genes (cis-aconitate decarboxylase (CAD) encoding gene

SUBMITTER: Feng J 

PROVIDER: S-EPMC9798595 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature