Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort.

ABSTRACT:

Background

High dietary glycaemic index (GI) and load (GL) have been associated with increased risk of various cardiometabolic conditions. Among the molecular potential mechanisms underlying this relationship, DNA methylation has been studied, but a direct link between high GI and/or GL of diet and global DNA methylation levels has not been proved yet. We analyzed the associations between GI and GL and global DNA methylation patterns within an Italian population.

Results

Genomic DNA methylation (5mC) and hydroxymethylation (5hmC) levels were measured in 1080 buffy coat samples from participants of the Moli-sani study (mean(SD) = 54.9(11.5) years; 52% women) via ELISA. A 188-item Food Frequency Questionnaire was used to assess food intake and dietary GI and GL for each partic

SUBMITTER: Noro F 

PROVIDER: S-EPMC9798643 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature