Acidic and hypoxic tumor microenvironment regulation by CaO₂-loaded polydopamine nanoparticles.

ABSTRACT: Hypoxia and high accumulation of lactic acid in the tumor microenvironment provide fertile soil for tumor development, maintenance and metastasis. Herein, we developed a calcium peroxide (CaO₂)-loaded nanostructure that can play a role of "one stone kill two birds", i.e., acidic and hypoxic tumor microenvironment can be simultaneously regulated by CaO₂ loaded nanostructure. Specifically, CaO₂-loaded mesoporous polydopamine nanoparticles modified with sodium hyaluronate (denoted as CaO₂@mPDA-SH) can gradually accumulate in a tumor site. CaO₂ exposed in acidic microenvironment can succeed in consuming the lactic acid with oxygen generation simultaneously, which could remodel the acid and hypoxia tumor microenvironment. More importantly,

SUBMITTER: Ruan S 

PROVIDER: S-EPMC9798656 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature